In this study, the effect of ultrasound (US) on the quartz-amine flotation system was investigated in detail by considering various surface chemistry techniques. The effect of ultrasound on particle size, shape factor, and surface roughness were characterized by using Brunauer-Emmett-Teller (BET) surface area measurements and scanning electron microscopy (SEM) analyses. The contact angle and bubble-particle attachment time, as well as adsorption density measurements was carried out to evaluate the effect of ultrasound on quartz surface wetting ability. In addition, atomic force microscopy (AFM) analyses were conducted, and finally micro-flotation studies were performed. As a result, it was found that the micro-flotation recovery at 2 x 10(-5) M dodecyl amine hydrochloride (DAH) concentration increased from 45.45% to 63.64% with 30 W ultrasonic application at conditioning step. However, the micro-flotation recovery decreased to 37.50% when the ultrasonic power increased to 150 W. The results showed some effect of ultrasound on particle size, particle shape, and surface roughness in some extent. The increase in the contact angle and the decrease in the bubble-particle attachment time were observed. A slightly high adsorption density was measured. All these show a positive effect of ultrasound on quartz flotation with amine as a collector.