Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury
ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.23, sa.6, ss.452-458, 2017 (SCI-Expanded, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 23 Sayı: 6
- Basım Tarihi: 2017
- Doi Numarası: 10.5505/tjtes.2017.09694
- Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.452-458
- Anahtar Kelimeler: Apoptosis, caspases, necrosis, neuroprotection, NMDA receptor antagonist, pancaspase inhibitor, Q-VD-OPh, riluzole, spinal cord injury, FOCAL CEREBRAL-ISCHEMIA, STRIATONIGRAL DEGENERATION, CASPASE-3 INHIBITOR, APOPTOSIS, RAT, IMPROVES, PHARMACOTHERAPY, MECHANISMS, MEMANTINE, RECOVERY
- İstanbul Üniversitesi Adresli: Evet
Özet
BACKGROUND: We investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury.