Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury

Can H., Aydoseli A., Gomleksiz C., Goker B., Altunrende M. E., Dolgun M., ...More

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, vol.23, no.6, pp.452-458, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 23 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.5505/tjtes.2017.09694
  • Journal Name: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.452-458
  • Keywords: Apoptosis, caspases, necrosis, neuroprotection, NMDA receptor antagonist, pancaspase inhibitor, Q-VD-OPh, riluzole, spinal cord injury, FOCAL CEREBRAL-ISCHEMIA, STRIATONIGRAL DEGENERATION, CASPASE-3 INHIBITOR, APOPTOSIS, RAT, IMPROVES, PHARMACOTHERAPY, MECHANISMS, MEMANTINE, RECOVERY
  • Istanbul University Affiliated: Yes

Abstract

BACKGROUND: We investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury.