Combined and individual use of pancaspase inhibitor Q-VD-OPh and NMDA receptor antagonist riluzole in experimental spinal cord injury

Can H., Aydoseli A., Gomleksiz C., Goker B., Altunrende M. E., Dolgun M., ...Daha Fazla

ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY, cilt.23, sa.6, ss.452-458, 2017 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 23 Sayı: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.5505/tjtes.2017.09694
  • Dergi Adı: ULUSAL TRAVMA VE ACIL CERRAHI DERGISI-TURKISH JOURNAL OF TRAUMA & EMERGENCY SURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.452-458
  • Anahtar Kelimeler: Apoptosis, caspases, necrosis, neuroprotection, NMDA receptor antagonist, pancaspase inhibitor, Q-VD-OPh, riluzole, spinal cord injury, FOCAL CEREBRAL-ISCHEMIA, STRIATONIGRAL DEGENERATION, CASPASE-3 INHIBITOR, APOPTOSIS, RAT, IMPROVES, PHARMACOTHERAPY, MECHANISMS, MEMANTINE, RECOVERY
  • İstanbul Üniversitesi Adresli: Evet

Özet

BACKGROUND: We investigated the effects of an N-methyl-D-aspartate receptor antagonist, riluzole, and a pancaspase inhibitor and basic apoptosis mediator, Q-VD-OPh, in combination or alone in posttraumatic spinal cord injury.