Connective tissue growth factor in drug-induced gingival overgrowth


Uzel M., Kantarci A., Hong H., Uygur C., Sheff M., Firatli E., ...More

JOURNAL OF PERIODONTOLOGY, vol.72, no.7, pp.921-931, 2001 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 72 Issue: 7
  • Publication Date: 2001
  • Doi Number: 10.1902/jop.2001.72.7.921
  • Journal Name: JOURNAL OF PERIODONTOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.921-931
  • Keywords: gingival hyperplasia/etiology, growth factors, connective tissue, growth factors, transforming, VASCULAR ENDOTHELIAL-CELLS, MONOCYTE CHEMOATTRACTANT PROTEIN-1, FACTOR GENE-EXPRESSION, ANGIOGENESIS IN-VIVO, CYCLOSPORINE-A, ADHESION MOLECULE, FACTOR-BETA, HYPERPLASIA, NIFEDIPINE, PHENYTOIN
  • Istanbul University Affiliated: Yes

Abstract

Background: Drug-induced gingival overgrowth is a known side effect of certain chemotherapeutic agents used for the treatment of systemic disorders. The pathogenesis and mechanisms responsible for this condition are not fully understood. This study assesses for the presence and localization of connective tissue growth factor (CTGF) in drug-induced gingival overgrowth tissues. CTGF immunostaining was compared with sections stained with transforming growth factor (TGF)-beta1 and CD31 antibodies in order to investigate possible pathogenic mechanisms.