Connective tissue growth factor in drug-induced gingival overgrowth

Uzel M., Kantarci A., Hong H., Uygur C., Sheff M., Firatli E., ...Daha Fazla

JOURNAL OF PERIODONTOLOGY, cilt.72, sa.7, ss.921-931, 2001 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 72 Sayı: 7
  • Basım Tarihi: 2001
  • Doi Numarası: 10.1902/jop.2001.72.7.921
  • Dergi Adı: JOURNAL OF PERIODONTOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.921-931
  • Anahtar Kelimeler: gingival hyperplasia/etiology, growth factors, connective tissue, growth factors, transforming, VASCULAR ENDOTHELIAL-CELLS, MONOCYTE CHEMOATTRACTANT PROTEIN-1, FACTOR GENE-EXPRESSION, ANGIOGENESIS IN-VIVO, CYCLOSPORINE-A, ADHESION MOLECULE, FACTOR-BETA, HYPERPLASIA, NIFEDIPINE, PHENYTOIN
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background: Drug-induced gingival overgrowth is a known side effect of certain chemotherapeutic agents used for the treatment of systemic disorders. The pathogenesis and mechanisms responsible for this condition are not fully understood. This study assesses for the presence and localization of connective tissue growth factor (CTGF) in drug-induced gingival overgrowth tissues. CTGF immunostaining was compared with sections stained with transforming growth factor (TGF)-beta1 and CD31 antibodies in order to investigate possible pathogenic mechanisms.