Genetic Variation in NFKB1 Gene Influences Liver Enzyme Levels in Morbidly Obese Women

Yenmis G., Soydas T., Arkan H., TAŞAN E., Sultuybek G. K.

ARCHIVES OF IRANIAN MEDICINE, vol.21, no.1, pp.13-18, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 21 Issue: 1
  • Publication Date: 2018
  • Journal Name: ARCHIVES OF IRANIAN MEDICINE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.13-18
  • Istanbul University Affiliated: Yes

Abstract

Background: Morbid obesity (MO), characterized by low-grade inflammation, is associated with increased C-reactive protein (CRP). NF-KB is a candidate factor for inflammatory responses in inflammatory diseases such as obesity. The objective of our study was to investigate the relationship between NFKB1 gene variations and the risk of MO in the context of the high/normal level of liver enzymes such as Alanine aminotransferase (ALT), Aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), and alkaline phosphatase (ALP).