Association between synovial fluid prostanoid levels and ultrasonographic findings in knee osteoarthritis


ÖZEN G., ŞEN E. İ., ÇELİK Z., ŞAHBAZ T., TOPAL TANYILMAZ G., DIRAÇOĞLU D.

CUKUROVA MEDICAL JOURNAL, cilt.46, sa.3, ss.934-943, 2021 (ESCI) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 3
  • Basım Tarihi: 2021
  • Doi Numarası: 10.17826/cumj.899751
  • Dergi Adı: CUKUROVA MEDICAL JOURNAL
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.934-943
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose. The aim of this study was to investigate the association between prostanoid [thromboxane (TxA2) and prostacyclin (PGI2)] levels in synovial fluid and infrapatellar fat pad (IPFP)/ suprapatellar fat pad (SPFP) thickness as well as other clinical findings in knee steoarthritis (OA) patients. Materials and Methods: 16 patients with knee OA with effusion were included. The average pain levels were evaluated using a Visual Analogue Scale (VAS). The pain, stiffness, and physical functions were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The levels of 6-keto-PGF1α, stable metabolite of PGI2, and TxB2, stable metabolite of TxA2, were measured in synovial fluid using an enzyme immunoassay. Results: 6-keto-PGF1α levels were significantly greater than TxB2 levels in synovial fluid of patients with OA. TxB2 levels and TxB2/6-keto- PGF1α ratio were negatively correlated with SPFP and cartilage thickness, respectively. IPFP thickness was positively correlated with SPFP thickness and effusion volume. WOMAC scores were positively correlated with VAS-activity and VAC-evening scores. Conclusion: In comparison to 6-keto- PGF1α levels in synovial fluid, TxB2 levels seem to be more associated with ultrasonographic findings in patients with OA