Association between synovial fluid prostanoid levels and ultrasonographic findings in knee osteoarthritis

Özen G., Şen E. İ., Çelik Z., Şahbaz T., Topal Tanyılmaz G., Dıraçoğlu D.

Cukurova Medical Journal, no.46, pp.934-943, 2021 (ESCI)

  • Publication Type: Article / Article
  • Publication Date: 2021
  • Doi Number: 10.17826/cumj.899751
  • Journal Name: Cukurova Medical Journal
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Academic Search Premier, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.934-943
  • Istanbul University Affiliated: Yes


Purpose. The aim of this study was to investigate the association between prostanoid [thromboxane (TxA2) and prostacyclin (PGI2)] levels in synovial fluid and infrapatellar fat pad (IPFP)/ suprapatellar fat pad (SPFP) thickness as well as other clinical findings in knee steoarthritis (OA) patients. Materials and Methods: 16 patients with knee OA with effusion were included. The average pain levels were evaluated using a Visual Analogue Scale (VAS). The pain, stiffness, and physical functions were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). The levels of 6-keto-PGF1α, stable metabolite of PGI2, and TxB2, stable metabolite of TxA2, were measured in synovial fluid using an enzyme immunoassay. Results: 6-keto-PGF1α levels were significantly greater than TxB2 levels in synovial fluid of patients with OA. TxB2 levels and TxB2/6-keto- PGF1α ratio were negatively correlated with SPFP and cartilage thickness, respectively. IPFP thickness was positively correlated with SPFP thickness and effusion volume. WOMAC scores were positively correlated with VAS-activity and VAC-evening scores. Conclusion: In comparison to 6-keto- PGF1α levels in synovial fluid, TxB2 levels seem to be more associated with ultrasonographic findings in patients with OA