Iatrogenic Botulism After Botulinum Toxin Type A Injections

Coban A., Matur Z., Hanagasi H. A., Parman Y.

CLINICAL NEUROPHARMACOLOGY, vol.33, no.3, pp.158-160, 2010 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 33 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.1097/wnf.0b013e3181d479e0
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.158-160
  • Keywords: iatrogenic botulism, botulinum toxin A, spasticity, blepharospasm, LOCAL INJECTIONS, DISTANT, NEUROTOXIN
  • Istanbul University Affiliated: Yes


Therapeutic use of botulinum toxin type A (BT/A) is well known, effective, and safe. Iatrogenic botulism that presents with generalized weakness, dysphagia, and respiratory distress is a rare but significant complication in BT/A treatment. In this study, we report 4 patients who developed iatrogenic botulism after receiving therapeutic doses of BT/A for spasticity and blepharospasm. One patient was placed in intensive care unit, but consequently, every patient recovered fully. The cause of BT/A as an adverse effect is most likely hematological spread of the toxin.