Clinical features and molecular genetic analysis in a Turkish family with oral white sponge nevus


Kurklu E., Ozturk S. , Cassidy A. J. , Ak G., Koray M., Cefle K. , ...Daha Fazla

MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL, cilt.23, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 23 Konu: 2
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4317/medoral.21437
  • Dergi Adı: MEDICINA ORAL PATOLOGIA ORAL Y CIRUGIA BUCAL

Özet

Background: Oral white sponge nevus (WSN) is a rare autosomal dominant benign condition, characterized by asymptomatic spongy white plaques. Mutations in Keratin 4 (KRT4) and 13 (KRT13) have been shown to cause WSN. Familial cases are uncommon due to irregular penetrance. Thus, the aim of the study was: a) to demonstrate the clinical and histopathological features of a three-generation Turkish family with oral WSN b) to determine whether KRT4 or KRT13 gene mutation was the molecular basis of WSN.