Effects of Intrathecai Verapamil on Cerebral Vasospasm in Experimental Rat Study

Akkaya E., Evran S., Calis F., Cevik S., Hanimoglu H., SEYİTHANOĞLU M. H., ...Daha Fazla

WORLD NEUROSURGERY, cilt.127, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 127
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.wneu.2019.04.050
  • Dergi Adı: WORLD NEUROSURGERY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • İstanbul Üniversitesi Adresli: Hayır

Özet

BACKGROUND: Verapamil a calcinarn channel blacker, has shown promising results on cerebral vasospasm. However, it has not yet been accepted for treatment or prevention purposes because of the associated side effects, Although the effective results of nimodipine and nicardipine's intrathecal administration are well known, intrathecal verapamil has not been considered earlier. We used an experimental subarachnoid hemorrhage induced vasospasm model for the evaluation of vasodilator and neuroprotective effects of intrathecal verapamil,