Effect of cytochrome P450 2C19 polymorphisms on the Helicobacter pylori eradication rate following two-week triple therapy with pantoprazole or rabeprazole


Ormeci A., Emrence Z. , Baran B., Gokturk S., Soyer O. M. , Evirgen S., ...Daha Fazla

European Review for Medical and Pharmacological Sciences, cilt.20, ss.879-885, 2016 (SCI Expanded İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 20 Konu: 5
  • Basım Tarihi: 2016
  • Dergi Adı: European Review for Medical and Pharmacological Sciences
  • Sayfa Sayıları: ss.879-885

Özet

OBJECTIVE: Cytochrome P450 2C19 (CYP2C19) polymorphisms play an important role in the metabolism of proton pump inhibitors. Rabeprazole is primarily metabolized via non-enzymatic pathways. In this study, we determined whether rabeprazole- and pantoprazole-based eradication treatments were influenced by CYP2C19 polymorphisms.