This study was conducted identify the cause of mortality in diseased Seven khramulya (Capoeta capoeta) and to determine the damage to the fish tissue caused by the agents identified. While hemorrhage on the fins and abdominal region of diseased fish, necrosis in gills, darkening color and loss of scales were externally determined, the presence of bloody and smelling liquid in the abdominal cavity, necrosis of visceral organs, splenomegaly, hyperemia and hemorrhage in the visceral organs were internally observed. As a result of the parasitological examination, Grrodactrlus sp. were found on the gills of the diseased fish. and Trichodina sp. were found on their skin. Bacteriologically. isolated bacteria were identified as Aeromonas hydrophila, Vibrio fluvialis, Staphylococcus warneri and S capitis. Histopathologically, thickening of epicardium in heart tissue, myopathy, periglomerular and tubular edema melanomacrophage and hemosiderin foci, the infiltration of inflammatory cells in the kidney, hyperemia, infiltration of inflammatory cells in the liver were observed. A. hydrophila, V. fluvialis, S warneri, and S capitis were first isolated and identified as disease agents from the co-infection in diseased Seven khyramulya, and furthermore, pathological changes in tissues caused by these pathogenic bacteria were investigated in detail.