Association between PTEN IVS4 polymorphism and development of colorectal cancer in a Turkish population

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Canbay E., Kahraman O. T., BUĞRA D., Caykara B., Seyhan M. F., Bulut T., ...More

EXPERT OPINION ON THERAPEUTIC TARGETS, vol.17, no.1, pp.1-6, 2013 (SCI-Expanded)

• Publication Type: Article / Article
• Volume: 17 Issue: 1
• Publication Date: 2013
• Doi Number: 10.1517/14728222.2013.727398
• Journal Name: EXPERT OPINION ON THERAPEUTIC TARGETS
• Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Page Numbers: pp.1-6
• Istanbul University Affiliated: Yes

Abstract

Background: Phosphatase and tensin homolog (PTEN) is one of the most frequently mutated suppressor genes in human cancers. However, there are no data about the role of PTEN IVS4 polymorphism in development of colorectal cancer (CRC). The authors aimed to determine the role of PTEN IVS4 variants in the etiology of CRC.