PREDICTORS OF INTRALUMINAL RECURRENCE AT THE ANASTOMOSIS SITE AFTER CURATIVE RESECTION FOR COLON CANCER


ÖZGÜR İ., Celik B., BÜYÜK M., ERTEKİN C., Bulut T., KESKİN M.

JOURNAL OF ISTANBUL FACULTY OF MEDICINE-ISTANBUL TIP FAKULTESI DERGISI, 2024 (ESCI) identifier

Abstract

Objective: The increase in the number of patients recovering from colon cancer after primary resection inevitably increases the number of patients with local recurrence. This study was conducted to investigate the predictors of intraluminal recurrence at the anastomosis site in patients who underwent curative resection for colon cancer. Material and Method: This study included 160 patients who underwent curative resection for colon cancer and had completed follow-up colonoscopy and surveillance for at least two years at our tertiary referral hospital. Patients with intraluminal recurrence were compared with those without locally recurrent disease. Patient data, including demographics, tumor characteristics, surgery type, and reconstruction technique, were reviewed. Result: The median age of the study group was 61 years, and 60% were men. A total of 25 (15.6%) patients had only intraluminal recurrence at the anastomosis site. The median time to intraluminal recurrence was 21.3 months (range, 3-71 months). Univariate analysis revealed the histopathological type, histological grade, T stage, number of metastatic lymph nodes, tumor margins, presence of tumor budding, perineural invasion, and anastomosis type as risk factors for intraluminal recurrence. Multivariate analysis revealed handsewn anastomoses (odds ratio [OR]: 45.532; 95% confidence interval (CI): 5.278-392.778), T stage (OR: 3.593; 95% CI: 1.378-9.371), and the presence of tumor budding (OR: 3.912; 95% CI: 1.306-11.715) as independent risk factors. Adjuvant chemotherapy did not affect the rate of intraluminal recurrence. Conclusion: This study suggests a relationship between tumor biology and intraluminal recurrence, and the T stage and tumor budding were the predictors.