P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome

DIZ-KUCUKKAYA R., Inanc M., AFSHAR-KHARGHAN V., ZHANG Q. E., LOPEZ J. A., Pekcelen Y.

ANNALS OF THE RHEUMATIC DISEASES, vol.66, no.10, pp.1378-1380, 2007 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 66 Issue: 10
  • Publication Date: 2007
  • Doi Number: 10.1136/ard.2007.075945
  • Journal Name: ANNALS OF THE RHEUMATIC DISEASES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1378-1380
  • Istanbul University Affiliated: Yes

Abstract

Objectives: Antiphospholipid antibodies (aPLA) have been shown to enhance thrombus formation by increasing the expression of adhesive receptors such as P-selectin on endothelial cells. The P-selectin counter-receptor on leucocytes is P-selectin glycoprotein ligand-1 (PSGL-1). We have previously described a variable number of tandem repeats ( VNTR) polymorphism in the mucin-like region of PSGL-1, with three alleles: allele A, 16 repeats; allele B, 15 repeats; and allele C, 14 repeats.