P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome

DIZ-KUCUKKAYA R., Inanc M., AFSHAR-KHARGHAN V., ZHANG Q. E., LOPEZ J. A., Pekcelen Y.

ANNALS OF THE RHEUMATIC DISEASES, cilt.66, sa.10, ss.1378-1380, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 66 Sayı: 10
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1136/ard.2007.075945
  • Dergi Adı: ANNALS OF THE RHEUMATIC DISEASES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1378-1380
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objectives: Antiphospholipid antibodies (aPLA) have been shown to enhance thrombus formation by increasing the expression of adhesive receptors such as P-selectin on endothelial cells. The P-selectin counter-receptor on leucocytes is P-selectin glycoprotein ligand-1 (PSGL-1). We have previously described a variable number of tandem repeats ( VNTR) polymorphism in the mucin-like region of PSGL-1, with three alleles: allele A, 16 repeats; allele B, 15 repeats; and allele C, 14 repeats.