Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma


Erdem M., Erdem S. , Sanli O., Sak H., Kilicaslan I., Sahin F., ...Daha Fazla

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.32, sa.1, 2014 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 32 Konu: 1
  • Basım Tarihi: 2014
  • Doi Numarası: 10.1016/j.urolonc.2012.08.022
  • Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Özet

Objective: Tissue transglutaminase (TGM2) up-regulation is involved in the progression and dissemination of carcinomas through 131 integrin (ITGB1) association. Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we investigated the roles of TG.M2. ITGB1, and SDC4 in the development and metastasis of renal cell carcinoma (RUC).