Up-regulation of TGM2 with ITGB1 and SDC4 is important in the development and metastasis of renal cell carcinoma
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS, cilt.32, sa.1, 2014 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 32 Sayı: 1
- Basım Tarihi: 2014
- Doi Numarası: 10.1016/j.urolonc.2012.08.022
- Dergi Adı: UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Anahtar Kelimeler: Tissue transglutaminase, Renal cell carcinoma, Integrin beta 1, Syndecan-4, Metastasis, TISSUE TRANSGLUTAMINASE EXPRESSION, FIBRONECTIN, ADHESION, SYNDECAN-4, ATTACHMENT, SURVIVAL, PROMOTES, TG2
- İstanbul Üniversitesi Adresli: Evet
Özet
Objective: Tissue transglutaminase (TGM2) up-regulation is involved in the progression and dissemination of carcinomas through 131 integrin (ITGB1) association. Given that TGM2 interaction with syndecan-4 (SDC4) on the cell surface is important in the activation of ITGB1 and integrin-mediated survival signaling, we investigated the roles of TG.M2. ITGB1, and SDC4 in the development and metastasis of renal cell carcinoma (RUC).