Prevalence of Beta-Thalassemia Trait and Abnormal Hemoglobins in the Province of Adiyaman, Turkey

Genc A., Korkmaz D. T., Kucuk M. U., Rencuzogullari E., Atakur S., Bayram S., ...Daha Fazla

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.29, sa.7, ss.620-623, 2012 (SCI-Expanded) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 29 Sayı: 7
  • Basım Tarihi: 2012
  • Doi Numarası: 10.3109/08880018.2012.713085
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.620-623
  • İstanbul Üniversitesi Adresli: Evet

Özet

Background/Aims: Thalassemia is one of the most common hereditary disorders in Turkey. The aim of this study was to determine the prevalence of the beta-thalassemia trait and abnormal hemoglobins in the province of Adiyaman in Turkey. Methods: The study included 3571 high school students of both sexes; aged 12-22 (mean 16.59 +/- 1.34). After they received information about thalassemia, they were screened for beta-thalassemia and abnormal hemoglobin using complete blood count (CBC) and quantification of hemoglobin. Hemoglobin was fractionated using HPLC. Results: The beta-thalassemia trait was found in 38 students (1.06%), and abnormal hemoglobin in seven students (0.20%). Of the latter, four carried HbD Los Angeles, two HbS, and one HbE-Saskatoon. Conclusion: The prevalence of the beta-thalassemia trait and abnormal hemoglobin in the province of Adiyaman is low, compared to the rest of Turkey. Our results seem to reflect the heterogeneity of beta-thalassemia in the province of Adiyaman and may be of value for genetic counseling and premarital screening.