Apoptotic effects of acacetin in human colon cancer HT-29 and HCT 116 cells


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Aslans B. T., ERTUĞRUL B., Iplik E. S., ÇAKMAKOĞLU B.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, vol.17, no.6, pp.1479-1482, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2021
  • Doi Number: 10.4103/jcrt.jcrt_1097_19
  • Journal Name: JOURNAL OF CANCER RESEARCH AND THERAPEUTICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, MEDLINE, Veterinary Science Database
  • Page Numbers: pp.1479-1482
  • Keywords: Anticancer, apoptosis, caspase, colorectal, flavonoid, EXPRESSION
  • Istanbul University Affiliated: Yes

Abstract

Aim: Acacetin is a natural flavone compound, which is found in several plants as Robinia pseudoacacia and is demonstrated to have anticancerogenic activities in many types of cancer (e.g., human nonsmall cell lung cancer, and prostate). Colorectal carcinoma (CRC) is one of the serious health problems and is a complex disease. We intended to find a more effective new candidate for the treatment of colon cancer, and hence, we designed this study to investigate the effects of acacetin on CRC (HT-29, HCT 116) in vitro.