Association of APOE polymorphisms with disease severity in MS is limited to women

Kantarci O., Hebrink D., Achenbach S., Pittock S., Altintas A., Schaefer-Klein J., ...Daha Fazla

NEUROLOGY, cilt.62, sa.5, ss.811-814, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 62 Sayı: 5
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1212/01.wnl.0000113721.83287.83
  • Dergi Adı: NEUROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.811-814
  • İstanbul Üniversitesi Adresli: Hayır

Özet

The authors studied the association of an exon 4 (E4* epsilon2/3/4) and three promoter polymorphisms of APOE with disease course and severity stratified by gender in 221 patients with multiple sclerosis from two overlapping population-based prevalence cohorts. Women carriers of the E4* epsilon2 allele took longer to attain an Expanded Disability Status Scale score of 6 ( p = 0.015) and had more favorable ranked severity scores than noncarriers ( p = 0.009). There was no association in men. Alleles epsilon3 or epsilon4 and promoter polymorphisms were not associated with disease course or severity.