A new series of Cu(II) and Ni(II) complexes of NO bidentate 4-NO2-benzoylhydrazones: synthesis, characterization, and biological studies

Kucuk H. B., Kara E. M., Celik B.

TURKISH JOURNAL OF CHEMISTRY, vol.39, no.5, pp.939-954, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 39 Issue: 5
  • Publication Date: 2015
  • Doi Number: 10.3906/kim-1502-122
  • Journal Name: TURKISH JOURNAL OF CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.939-954
  • Keywords: Hydrazone derivatives, bidentate Schiff base ligand, copper complex, nickel complex, antimicrobial activity, COPPER(II) COMPLEXES, CORROSION INHIBITION, CRYSTAL-STRUCTURES, PROTEIN-BINDING, SCHIFF-BASES, ACID, ANTIOXIDANT, NICKEL(II), COBALT(II), CHEMISTRY
  • Istanbul University Affiliated: Yes

Abstract

A series of new nickel(II) and copper(II) hydrazone complexes 1-14, containing a bidentate NO-donor hydrazone ligand, derived from 4-nitrobenzoylhydrazide and several aliphatic and aromatic aldehydes were synthesized, and their chemical structures were confirmed by means of FT-IR, UV-Vis, H-1 and C-13 NMR, mass spectral data, conductance measurements, and elemental analyses. The spectral data of the newly synthesized complexes show the formation of a 1:2 [metal:ligand] ratio. The ligands and their complexes were also investigated for their possible in vitro antimicrobial activities against S. atreus, S. epidermidis, E. coli, K. pneumonia, P. aeruginosa, P. mirabilis, E. faecalis, and C. albicans. Among the fourteen new complexes synthesized, complex Cu(L-4)(2) (7) containing a direct aromatic moiety in the ligand (HL7) was found to be most active against selected test microorganisms.