The effect of 1,25-dihydroxyvitamin D3 on liver damage, oxidative stress, and advanced glycation end products in experimental nonalcoholic- and alcoholic- fatty liver disease


Bingul I. , Aydin A. F. , Kucukgergin C. , Dogan-Ekici I., Dogru-Abbasoglu S. , Uysal M.

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.51, no.3, pp.1500-1511, 2021 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 51 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.3906/sag-2007-289
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded
  • Page Numbers: pp.1500-1511
  • Keywords: Vitamin D, fructose, ethanol, oxidative stress, glycation end products, VITAMIN-D PREVENTS, METABOLIC SYNDROME, BETAINE TREATMENT, D DEFICIENCY, RATS, ANTIOXIDANT, FIBROSIS, INJURY, SUPPLEMENTATION, INFLAMMATION

Abstract

Background/aim: Oxidative stress and advanced glycation end products (AGEs) formation are proposed as effective mechanisms in the pathogenesis of nonalcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). 1,25(OH)(2)D-3 was proposed to have antioxidant, antiinflammatory and antiglycation properties. In this study, the effect of 1,25(OH)(2)D-3 treatment on oxidative stress parameters and AGEs levels together with hepatic histopathology was investigated in high fructose (HFr) or ethanol (EtOH)-treated rats.