Synthesis and Aldose Reductase Inhibitory Effect of Some New Hydrazinecarbothioamides and 4-Thiazolidinones Bearing an Imidazo[2,1-b] Thiazole Moiety

Ulusoy Guzeldemirci N., Cimok S., Das-Evcimen N., Sarikaya M.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.16, no.1, pp.1-7, 2019 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 16 Issue: 1
  • Publication Date: 2019
  • Doi Number: 10.4274/tjps.05900
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.1-7
  • Keywords: Hydrazinecarbothioamide, 4-thiazolidinone, imidazo[2,1-b]thiazole, aldose reductase inhibition, ANTICONVULSANT ACTIVITY, BIOLOGICAL-ACTIVITY, INSULIN-RESISTANCE, DERIVATIVES, THIAZOLIDINEDIONES, COMPLICATIONS, NIDDM
  • Istanbul University Affiliated: Yes

Abstract

Objectives: To synthesize and characterize 2-[[6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl]acetyl]-N-alkyl/arylhydrazinecarbothioamide and 3-alkyl/aryl-2-[((6-(4-bromophenyl)imidazo[2,1-b]thiazol-3-yl)acetyl)hydrazono]-5-nonsubstituted/methyl-4-thiazolidinone derivatives and evaluate them for their aldose reductase (AR) inhibitory effect.