The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

Dursun, Erdinç; Gezen-Ak, Duygu; Hanagasi, HAŞMET; Bilgic, BAŞAR; Lohmann, Ebba; Ertan, Sibel; Atasoy, Irem; Alaylioglu, Merve; Araz, Omur; Onal, Burak; Gunduz, Aysegul; Apaydin, Hülya; Kiziltan, Gunes; Ulutin, Turgut; Gurvit, İBRAHİM; Yilmazer, Selma

doi:10.1016/j.jneuroim.2015.04.014

The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

Dursun E., Gezen-Ak D., Hanagasi H. A., Bilgic B., Lohmann E., Ertan S., ...Daha Fazla

Journal of Neuroimmunology, cilt.283, ss.50-57, 2015 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 283
Basım Tarihi: 2015
Doi Numarası: 10.1016/j.jneuroim.2015.04.014
Dergi Adı: Journal of Neuroimmunology
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.50-57
Anahtar Kelimeler: Alzheimer's disease, Mild cognitive impairment (MCI), Parkinson's disease (PD), Interleukin 1 alpha (IL-1 alpha), Interleukin 1 beta (IL-1 beta), Interleukin 6 (IL-6), Alpha-2 macroglobulin (alpha 2-macroglobulin), Tumor necrosis factor alpha (TNF alpha), Brain derived neurotrophic factor (BDNF), Interleukin 10 (IL-10), Heat shock protein 90 (Hsp90), Biomarker, NECROSIS-FACTOR-ALPHA, CEREBROSPINAL-FLUID, VASCULAR DEMENTIA, TNF-ALPHA, PLASMA-LEVELS, INFLAMMATORY MARKERS, CYTOKINES, IL-1-BETA, BRAIN, ALPHA(1)-ANTICHYMOTRYPSIN
İstanbul Üniversitesi Adresli: Evet

Özet

© 2015 Elsevier B.V.Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin (α2M) levels using ELISA.IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, α2M and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls.A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder.