The interleukin 1 alpha, interleukin 1 beta, interleukin 6 and alpha-2-macroglobulin serum levels in patients with early or late onset Alzheimer's disease, mild cognitive impairment or Parkinson's disease

Dursun E., Gezen-Ak D., Hanagasi H. A., Bilgic B., Lohmann E., Ertan S., ...More

Journal of Neuroimmunology, vol.283, pp.50-57, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 283
  • Publication Date: 2015
  • Doi Number: 10.1016/j.jneuroim.2015.04.014
  • Journal Name: Journal of Neuroimmunology
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.50-57
  • Keywords: Alzheimer's disease, Mild cognitive impairment (MCI), Parkinson's disease (PD), Interleukin 1 alpha (IL-1 alpha), Interleukin 1 beta (IL-1 beta), Interleukin 6 (IL-6), Alpha-2 macroglobulin (alpha 2-macroglobulin), Tumor necrosis factor alpha (TNF alpha), Brain derived neurotrophic factor (BDNF), Interleukin 10 (IL-10), Heat shock protein 90 (Hsp90), Biomarker, NECROSIS-FACTOR-ALPHA, CEREBROSPINAL-FLUID, VASCULAR DEMENTIA, TNF-ALPHA, PLASMA-LEVELS, INFLAMMATORY MARKERS, CYTOKINES, IL-1-BETA, BRAIN, ALPHA(1)-ANTICHYMOTRYPSIN
  • Istanbul University Affiliated: Yes

Abstract

© 2015 Elsevier B.V.Alzheimer's disease (EOAD, LOAD), mild cognitive impairment (MCI), Parkinson's disease (PD) and healthy controls were included to determine the serum interleukin-1s (IL-1α, IL-1β), IL-6 and alpha-2-macroglobulin (α2M) levels using ELISA.IL-6 might be a significant contributor to the inflammatory response in LOAD. The MCI data indicate that IL-1s, α2M and BDNF are somehow related, and this relationship might allow MCI patients to be more similar to the healthy controls.A correlation analysis of multiple biomarkers in different neurodegenerative disorders might be more useful than determining the levels of a single cytokine in a single disorder.