CONFORMATIONAL-ANALYSIS OF ARGIOPINE MOLECULE OBTAINED FROM ARGIOPE LOBATA SPIDER VENOM

GODJAYEV N., ALIYEVA I., AKYUZ S., ALIYEV C.

JOURNAL OF MOLECULAR STRUCTURE, cilt.350, sa.2, ss.173-183, 1995 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 350 Sayı: 2
  • Basım Tarihi: 1995
  • Doi Numarası: 10.1016/0022-2860(94)08470-3
  • Dergi Adı: JOURNAL OF MOLECULAR STRUCTURE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.173-183
  • İstanbul Üniversitesi Adresli: Hayır

Özet

The conformational behavior of argiopine, the molecule that blocks the glutamate-activated ion channels of the central nervous system in mammals, was investigated by theoretical conformational analysis. Realization of two types of structures, i.e. the pseudocyclic structure, formed by the hydrogen bonds between residues at the opposite ends of the molecule, and the entirely stretched-out structure, were shown to be possible for an isolated molecule. The molecular structure of argiopine essentially depends on the conditions in which the molecule functions.