CONFORMATIONAL-ANALYSIS OF ARGIOPINE MOLECULE OBTAINED FROM ARGIOPE LOBATA SPIDER VENOM


GODJAYEV N., ALIYEVA I., AKYUZ S., ALIYEV C.

JOURNAL OF MOLECULAR STRUCTURE, vol.350, no.2, pp.173-183, 1995 (Journal Indexed in SCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 350 Issue: 2
  • Publication Date: 1995
  • Doi Number: 10.1016/0022-2860(94)08470-3
  • Title of Journal : JOURNAL OF MOLECULAR STRUCTURE
  • Page Numbers: pp.173-183

Abstract

The conformational behavior of argiopine, the molecule that blocks the glutamate-activated ion channels of the central nervous system in mammals, was investigated by theoretical conformational analysis. Realization of two types of structures, i.e. the pseudocyclic structure, formed by the hydrogen bonds between residues at the opposite ends of the molecule, and the entirely stretched-out structure, were shown to be possible for an isolated molecule. The molecular structure of argiopine essentially depends on the conditions in which the molecule functions.