Association of major histocompatibility complex class I chain-related gene A and HLA-B alleles with Behcet's disease in Turkey

MIZUKI N., MEGURO A., TOHNAI I., Guel A., Ohno S., MIZUKI N.

JAPANESE JOURNAL OF OPHTHALMOLOGY, cilt.51, sa.6, ss.431-436, 2007 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51 Sayı: 6
  • Basım Tarihi: 2007
  • Doi Numarası: 10.1007/s10384-007-0473-y
  • Dergi Adı: JAPANESE JOURNAL OF OPHTHALMOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.431-436
  • Anahtar Kelimeler: Behcet's disease, HLA-B51, MICA, polymorphism, Turkish Behcet's patients, TRIPLET REPEAT POLYMORPHISM, MICA GENE, TRANSMEMBRANE REGION, T-CELLS, MICROSATELLITE POLYMORPHISM, ANKYLOSING-SPONDYLITIS, CAUCASIAN PATIENTS, SUSCEPTIBILITY, POPULATION, ACTIVATION
  • İstanbul Üniversitesi Adresli: Evet

Özet

Purpose: Behcet's disease (BD) is known to be associated with HLA-B*51 in many different ethnic groups. Recently, the major histocompatibility complex class I chain-related gene A (MICA), located near the HLA-B gene, has been proposed as a candidate gene for BD susceptibility in several ethnic groups. To compare the relative contribution of MICA polymorphisms and HLA-B*51 to BD in different ethnic groups, we studied MICA polymorphisms in Turkish BD patients.