Urine Levels of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Children with Type 1 Diabetes Mellitus

Yildirim, Zeynep; Yilmaz, Alev; Pehlivanoglu, Cemile; Gedikbasi, Asuman; Yuldiz, Mehmet; Dirican, Ahmet; Bundak, Riiyeycle; Darendeliler, Fatma; Emre, Sevinc; Nayir, Ahmet

doi:10.4274/jcrpe.galenos.2018.2018.0221

Urine Levels of Matrix Metalloproteinases and Tissue Inhibitor of Metalloproteinases in Children with Type 1 Diabetes Mellitus

Yildirim Z. N., Yilmaz A., Pehlivanoglu C., Gedikbasi A., Yuldiz M., Dirican A., ...Daha Fazla

JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY, cilt.11, sa.2, ss.157-163, 2019 (SCI-Expanded, Scopus, TRDizin)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 11 Sayı: 2
Basım Tarihi: 2019
Doi Numarası: 10.4274/jcrpe.galenos.2018.2018.0221
Dergi Adı: JOURNAL OF CLINICAL RESEARCH IN PEDIATRIC ENDOCRINOLOGY
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.157-163
Anahtar Kelimeler: Type 1 diabetes mellitus, diabetic nephropathy, children, biomarker, MMP, TIMP, NEPHROPATHY, MATRIX-METALLOPROTEINASE-9, EXPRESSION, DYSREGULATION, PATHOGENESIS, DISEASE, MMP-9
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Histopathological changes in the kidney in type I diabetes mellitus (T1DM) begin before detection of microalbuminuria. Therefore, there is interest in finding a better biomarker for the early detection of diabetic kidney injury. The aim of this present study was to determine whether urinary indicators of fibrosis are detectable early in the development of T1DM in children and if they may predict progressive renal injury.