Akademik Veri Yönetim Sistemi
ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, cilt.111, sa.5, ss.447-454, 2002 (SCI-Expanded)
We investigated the incidence of extracapsular spread (ECS) and the impact of ECS on contralateral neck metastasis in 67 patients with ipsilateral nodal metastasis (IpN+) whose records were extracted retrospectively from those of 155 laryngeal cancer patients. The incidence of ECS in association with variables was determined: T stage, N stage, tumor location, tumor extension, number of positive nodes, and contralateral neck status. The variables were evaluated to identify their impact on the rates of contralateral neck metastasis (CNM) and 3-year survival. Of the 67 patients, 30 (44.7%) had ECS. A significant relationship was found between ECS positivity and increased N stage, tumor extension up to the midline, number of positive nodes, and CNM (p=.04, p=.0001, p=.018. p=.0001, respectively). Multivariate analysis revealed that N stage (p=.002; odds ratio, 3.5517) and the presence of ECS (p=.0036; odds ratio, 7.7840) in IpN+ were associated with the greatest risk of CNM. The 3-year survival rate of patients with ipsilateral ECS was significantly lower than that of patients without ECS (43% versus 81%, p=.0002). Both CNM and presence of ECS in IpN+ emerged as significant independent predictors for survival with Cox multivariate analysis (p=.0086 and p=.0234, respectively). This result indicates the necessity of treating the contralateral NO neck in cases of IpN+ with ECS.