ICA-derived cortical responses indexing rapid multi-feature auditory processing in six-month-old infants


Piazza C., Cantiani C., Akalin-Acar Z., Miyakoshi M., Benasich A. A. , Reni G., ...More

NEUROIMAGE, vol.133, pp.75-87, 2016 (Journal Indexed in SCI) identifier

  • Publication Type: Article / Article
  • Volume: 133
  • Publication Date: 2016
  • Doi Number: 10.1016/j.neuroimage.2016.02.060
  • Journal Name: NEUROIMAGE
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.75-87
  • Keywords: Event-related potential, Rapid auditory discrimination, Infants, Independent component analysis, Source localization, EEG, EVENT-RELATED POTENTIALS, INDEPENDENT COMPONENT ANALYSIS, SOURCE LOCALIZATION, LANGUAGE-DEVELOPMENT, WORKING-MEMORY, BRAIN, ERP, MATURATION, FREQUENCY, ATTENTION
  • Istanbul University Affiliated: No

Abstract

The abilities of infants to perceive basic acoustic differences, essential for language development, can be studied using auditory event-related potentials (ERPs). However, scalp-channel averaged ERPs sum volume-conducted contributions from many cortical areas, reducing the functional specificity and interpretability of channel-based ERP measures. This study represents the first attempt to investigate rapid auditory processing in infancy using independent component analysis (ICA), allowing exploration of source-resolved ERP dynamics and identification of ERP cortical generators. Here, we recorded 60-channel EEG data in 34 typically developing 6-month-old infants during a passive acoustic oddball paradigm presenting 'standard' tones interspersed with frequency-or duration-deviant tones. ICA decomposition was applied to single-subject EEG data. The best-fitting equivalent dipole or bilaterally symmetric dipole pair was then estimated for each resulting independent component (IC) process using a four-layer infant head model. Similar brain-source ICs were clustered across subjects. Results showed ERP contributions from auditory cortex and multiple extra-auditory cortical areas (often, bilaterally paired). Different cortical source combinations contributed to the frequency-and duration-deviant ERP peak sequences. For ICs in an ERP-dominant source cluster located in or near the mid-cingulate cortex, source-resolved frequency-deviant response N2 latency and P3 amplitude at 6 months-of-age predicted vocabulary size at 20 months-of-age. The same measures for scalp channel F6 (though not for other frontal channels) showed similar but weaker correlations. These results demonstrate the significant potential of ICA analyses to facilitate a deeper understanding of the neural substrates of infant sensory processing. (C) 2016 Elsevier Inc. All rights reserved.