Biological activity and chemical composition of the essential oil from the fruits of Ferula rigidula Fisch. ex DC.
Acta Pharmaceutica Sciencia, vol.61, no.3, pp.257-268, 2023 (Scopus)
- Publication Type: Article / Article
- Volume: 61 Issue: 3
- Publication Date: 2023
- Doi Number: 10.23893/1307-2080.aps6117
- Journal Name: Acta Pharmaceutica Sciencia
- Journal Indexes: Scopus, EMBASE
- Page Numbers: pp.257-268
- Keywords: Antibacterial, anticandidal, essential oil, Ferula rigidula, GCMS
- Istanbul University Affiliated: Yes
Abstract
The hydro-distilled essential oils of the fruits of F. rigidula Fisch. ex DC. was analyzed by Gas Chromatography (GC) and Gas Chromatography/Mass Spectrometry (GC/MS) systems at the same time. Thirty-one compounds were characterized rep-resenting 98.2% of the essential oils. The main components of the oil were determined as a-pinene and camphene (24% and 20%, respectively). The anticandidal and antibacterial effects of the essential oil were determined by using partly modi-fied CLSI protocols M27-A2 and M7-A7, respectively. The essential oil of the dried fruits showed several inhibitory effects on the tested bacteria panel (MIC, 62.5 to 2000 µg/mL) and Candida species (MIC, 125 to 1000 µg/mL).