Impaired endothelium-dependent flow-mediated dilation in Behcet's disease: more prominent endothelial dysfunction in patients with vascular involvement

OFLAZ H., MERCANOGLU F., KARAMAN O., KAMALI S., ERER B., GENCHELLAC H., ...Daha Fazla

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, cilt.59, sa.7, ss.777-781, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 59 Sayı: 7
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1111/j.1742-1241.2005.00477.x
  • Dergi Adı: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.777-781
  • Anahtar Kelimeler: Behcet's disease, endothelial dysfunction, flow-mediated dilation, carotid artery intima-media thickness, SYSTEMIC VASCULITIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Brachial artery endothelial dysfunction was shown previously in a small group of Behcet's disease (BD) patients. This study aimed to compare the endothelial function in BD patients with and without vascular involvement. The study group consisted of 25 BD patients with vascular involvement, 25 BD patients without any vascular disease and 46 healthy controls. Brachial artery flow-mediated (endothelium-dependent) dilation (FMD), nitroglycerine-induced dilation and carotid artery intima-media thickness were measured. FMD was impaired in patients with BD (10.41 +/- 3.85%) compared to healthy controls (14.41 +/- 3.39%, p < 0.001). FMD was significantly lower in BD patients with vascular involvement (8.80 +/- 3.63%) than those without any vascular disease (12.02 +/- 3.43%, p = 0.003). This study reveals that endothelial dysfunction documented by brachial artery FMD is a feature of BD, and it is more prominent in patients with vascular involvement.