Association of CCL2 and CCR2 Gene Variants with Endometrial Cancer in Turkish Women

Attar R., Agachan B., Kuran S., Cacina C., Sozen S., Yurdum L. M., ...Daha Fazla

IN VIVO, cilt.24, sa.2, ss.243-248, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 24 Sayı: 2
  • Basım Tarihi: 2010
  • Dergi Adı: IN VIVO
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.243-248
  • Anahtar Kelimeler: CCL2, CCR2, polymorphism, endometrial cancer, chemokines, MONOCYTE CHEMOATTRACTANT PROTEIN-1, CHEMOKINE RECEPTOR CCR2, CHEMOTACTIC PROTEIN-1, MYOCARDIAL-INFARCTION, CXC-CHEMOKINES, OVARIAN-CANCER, SERUM-LEVELS, LUNG-CANCER, EXPRESSION, POLYMORPHISM
  • İstanbul Üniversitesi Adresli: Evet

Özet

Chemokines and their receptors play diverse roles in malignant tumor progression, particularly as key mediators of tumor stroma interactions. C-C motif chemokitze ligand 2 (CCL2) also called monocyte chemoattractant protein-1 (MCP-1), belongs to the C-C motif chemokine sub-family and is currently believed to mediate its actions through one receptor, C-C motif chemokitze receptor 2 (CCR2). CCL2 has been identified as a major chemokine inducing the recruitment of macrophages in human tumors, including those of the bladder, cervix, ovary, lung and breast. In this study of Turkish women, the association of CCL2 A2518G and CCR2 V64I polymorphisms with endometrial cancer was investigated using 50 endometrial cancer patients and 211 controls. In our study, individuals with CCL2 A2518G GG genotype showed a 6.7-fold increased risk for endometrial cancer (p<0.0001) and individuals with CCL2 A2518G A allele had a 7.14-fold lower risk of endometrium cancer (p<0.0001). Individuals carrying the CCR2 6411641 genotype had a 4.13-fold increased risk for endometrial cancer (p<0.0001). We also found that individuals carrying the CCR2 wt allele had a 4.16-fold lower risk for endometrial cancer (p=0.005). We observed that the CCL2 G: CCR2 641 haplotype frequency was significantly higher in patients compared to controls (p=0.019). In conclusion, we state that there appears to be an association between polymorphism of CCL2 and its receptor CCR2 and endometrial cancer. To the best of our knowledge, this is the first study to show such an association.