Comparing the Effects of Combined General/Epidural Anaesthesia and General Anaesthesia on Serum Cytokine Levels in Radical Cystectomy.

Karadeniz, Meltem; Mammadov, Orkhan; Ciftci, Hayriye; Usta, Sebahat; Pembeci, Kamil

doi:10.5152/tjar.2017.13285

Comparing the Effects of Combined General/Epidural Anaesthesia and General Anaesthesia on Serum Cytokine Levels in Radical Cystectomy.

Atıf İçin Kopyala

Karadeniz M. S., Mammadov O., Ciftci H., Usta S., Pembeci K.

Turkish journal of anaesthesiology and reanimation, cilt.45, sa.4, ss.203-209, 2017 (Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 45 Sayı: 4
Basım Tarihi: 2017
Doi Numarası: 10.5152/tjar.2017.13285
Dergi Adı: Turkish journal of anaesthesiology and reanimation
Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
Sayfa Sayıları: ss.203-209
İstanbul Üniversitesi Adresli: Evet

Özet

Objective: Surgical stress combined with general anaesthesia (GA) suppresses the immune system and leads to cancer cell growth and premature metastasis in major oncological interventions. Epidural analgesia decreases the need for inhalation agents and opioids during surgery by suppressing sympathetic and neuroendocrine responses in the postoperative period. This study aimed to compare the effects of combined general/epidural anaesthesia (GEA)+patient-controlled epidural analgesia (PCEA) and GA+IV patient-controlled analgesia (PCA) on serum tumour necrosis factor-alpha TNF-alpha), interleukin-1 beta (IL-1 beta) and interferon-gamma (IFN-gamma)levels in patients undergoing radical cystectomy.