Sildenafil citrate inhibits agonist induced contractions in isolated rat seminal vesicles


Orhan I., Onur R., Tasdemir C., Ayar A., Kadioglu A.

JOURNAL OF UROLOGY, cilt.175, ss.2350-2353, 2006 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 175 Konu: 6
  • Basım Tarihi: 2006
  • Doi Numarası: 10.1016/s0022-5347(06)00280-1
  • Dergi Adı: JOURNAL OF UROLOGY
  • Sayfa Sayıları: ss.2350-2353

Özet

Purpose: Sildenafil is reported to regulate smooth muscle contractility through nitric oxide-cyclic guanosine monophosphate, not only in the corpus cavernosum. Its possible effects on seminal vesicle contractility might be of importance with respect to premature ejaculation. We investigated the effects of sildenafil citrate (Pfizer, New York, New York) on agonist induced isometric contractions of the rat seminal vesicle in vitro.