Severe vitamin D deficiency is associated with endothelial inflammation in healthy individuals even in the absence of subclinical atherosclerosis

KÖSE M., ŞENKAL N., TÜKEK T., CEBECİ T., ATALAR S. C., ALTINKAYNAK M., ...Daha Fazla

EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, cilt.26, sa.19, ss.7046-7052, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 26 Sayı: 19
  • Basım Tarihi: 2022
  • Doi Numarası: 10.26355/eurrev_202210_29888
  • Dergi Adı: EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE, Directory of Open Access Journals
  • Sayfa Sayıları: ss.7046-7052
  • Anahtar Kelimeler: Key Endocan, Vitamin D deficiency, Atherosclerosis, Endothelial inflammation, ENDOCAN LEVELS, 25-HYDROXYVITAMIN-D, DISEASE, RISK, EXPRESSION, PREVENTION, CANCER, GENE
  • İstanbul Üniversitesi Adresli: Evet

Özet

- OBJECTIVE: Vitamin D has bene-ficial effects, some of which involve the cardio-vascular system. No study to date has investigat-ed the association between serum endocan levels, as a biomarker of endothelial inflammation, and vitamin D levels in the absence of subclinical atherosclerosis detected by carotid intima-media thickness (CIMT) in healthy individuals. PATIENTS AND METHODS: Subjects were categorized into three groups based on vitamin D levels according to Endocrine Society guide-lines. Mean CIMT was calculated from six mea-surements on two scans. Statistical significance was set at p < 0.05, and all testing was two-sided. RESULTS: The concentration of serum endocan was 802.8 +/- 411.4 ng/L in the group with the lowest serum vitamin D level, 454.8 +/- 334.3 ng/L in the mild/ moderately low serum vitamin D level group, and 269.4 +/- 180.2 ng/L in the group with normal serum vitamin D levels (p < 0.01). Receiver operating char-acteristics curve analysis revealed that a serum vita-min D concentration of 7.5 ng/mL had a 97% sensi-tivity and 81% specificity for the prediction of serum endocan level greater than 270 ng/L, which could be an indicator for endothelial inflammation. CONCLUSIONS: Demonstrating that vitamin D deficiency can cause endothelial damage in the early period of atherosclerosis without the development of clinical cardiovascular disease will have a pivotal role in the prevention of car-diovascular mortality and morbidity.