Outcome after hyperbaric oxygen treatment for cyclophosphamide-induced refractory hemorrhagic cystitis.

Kalayoglu-Besisik S. , Abdul-Rahman I., Erer B., Yenerel M. N. , Oguz F. , Tunc M., ...More

The Journal of urology, vol.170, no.3, pp.922, 2003 (Journal Indexed in SCI Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 170 Issue: 3
  • Publication Date: 2003
  • Doi Number: 10.1097/01.ju.0000080563.58561.c8
  • Title of Journal : The Journal of urology
  • Page Numbers: pp.922
  • Keywords: cystitis, hemorrhage, hyperbaric oxygenation, cyclophosphamide


Hemorrhagic cystitis (HC) following bone marrow transplantation (BMT) develops as a result of urothelial damage. Infection, medication and pelvic irradiation for cancer are the most common causes. The conventional management includes hyperhydration. Bladder irrigation by catheter placement and intravesical alum, prostaglandin F2 or formalin instillation is used in refractory cases. The course of HC may occasionally be associated with significant blood loss and worsened morbidity. We report a case of refractory HC treated successfully with hyperbaric oxygen.