One year in review 2021: Behcet's syndrome

Hatemi G., SEYAHİ E., Fresko I., Talarico R., Ucar D., Hamuryudan V.

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY, vol.39, no.5, 2021 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Review
  • Volume: 39 Issue: 5
  • Publication Date: 2021
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, CAB Abstracts, EMBASE, MEDLINE, Veterinary Science Database
  • Keywords: Behcet's syndrome, epidemiology, pathogenesis, outcome assessment, clinical findings, management, DISEASE, MANIFESTATIONS, EXPRESSION, EXPERIENCE
  • Istanbul University Affiliated: Yes


This review aims to provide a critical digest of the recent studies that enhance our understanding of Behcet's syndrome by evaluating time trends, differences in disease course between men and women, and between patients with an early and late disease onset, progress in disease assessment, novel findings on immunopathogenesis and genetics, clinical features and differential diagnosis of eye, vascular, nervous system and gastrointestinal system involvement, and new data on treatment modalities including TNF-alpha, IL-17 and IL-6 inhibitors, tofacitinib, and apremilast, as well as surgical interventions.