The effects of etodolac, nimesulid and naproxen sodium on the frequency of sister chromatid exchange after enclused third molars surgery.

Koeseoglu B., Oeztuerk Ş., Kocak H., Palanduz S., Cefle K.

Yonsei medical journal, vol.49, no.5, pp.742-7, 2008 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 49 Issue: 5
  • Publication Date: 2008
  • Doi Number: 10.3349/ymj.2008.49.5.742
  • Journal Name: Yonsei medical journal
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.742-7
  • Keywords: Genotoxicity, sister chromatid exchange, oral surgery, non-steroidal anti-inflammatory drugs, PERIPHERAL-BLOOD LYMPHOCYTES, CHROMOSOME-ABERRATION, ITALIAN POPULATION, PAIN, ZOMEPIRAC, INDUCTION, PLACEBO, DAMAGE, DRUGS, ACID
  • Istanbul University Affiliated: Yes


Purpose: Non-steroidal anti-inflammatory drugs (NSAID) are frequently used in oral surgical procedures in dentistry. The evaluation of the frequency of sister chromatid exchange (SCE) is accepted as a reliable cytogenctic method to assess the genotoxic effects of environmental factors. Materials and Methods: In this study, the genotoxic effects of various NSAIDs were assessed in 30 patients to who they were administered following encluosed third molar surgery using SCE analysis before and after the operation. The frequency of SCE was evaluated before the operation and after 3 days of etodolac, nimesulid and naproxen use. Results: There was no statistically significant difference in the frequency of SCE between the preoperative and postoperative states in patients given etodolac, nimesulid or naproxen sodium. Conclusion: Short term use of selective and non-selective NSAIDs was not associated with a significant genotoxic effect that could be detected using the SCE method in peripheric lymphocytes.