Effects of recombinant human growth hormone and nandrolone phenylpropionate on the healing of ischemic colon anastomosis in rats


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Yarimkaya A., Apaydin B. , Unal E., Karabicak I., Aydogan F., Uslu E., ...Daha Fazla

DISEASES OF THE COLON & RECTUM, cilt.46, ss.1690-1697, 2003 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 46 Konu: 12
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1007/bf02660777
  • Dergi Adı: DISEASES OF THE COLON & RECTUM
  • Sayfa Sayıları: ss.1690-1697

Özet

PURPOSE: Recombinant human growth hormone and nandrolone phenylpropionate are two different anabolic agents. This study was designed to investigate the effects of these anabolic agents on the heating of ischemic colon anastomosis in rats. METHODS: Seventy adult male Wistar rats were divided into five groups (n = 14). Group I was the sham laparotomy group. In the other groups, surgical procedures consisting of transsection and anastomosis were made at a distance 3 cm from the peritoneal reflection. Group II was the nonischemic control group. Ischemic colon model was produced in the remaining groups. Group III was the untreated control group. Groups IV and V received recombinant human growth hormone and nandrolone phenylpropionate, respectively. Bursting pressure and hydroxyproline levels were measured on the third and seventh postoperative days to evaluate anastomotic heating. RESULTS: Recombinant human growth hormone increased both collagen deposition and bursting pressure significantly at postoperative Days 3 and 7 compared with the sham and untreated control groups (P < 0.005). When compared with the untreated control, nandrolone phenylpropionate significantly increased collagen deposition at postoperative Days 3 and 7 (P < 0.005) and bursting pressure only at postoperative Day 3 (P < 0.005). CONCLUSIONS: Recombinant human growth hormone has more favorable therapeutic effects on the healing of ischemic colonic anastomoses than nandrolone phenylpropionate. Recombinant human growth hormone also improves healing of nonischemic colonic anastomosis.
growth
and
nandrolone
phenylpropionate
are
two
different
anabolic
This
study
was
to
investigate
the
effects
of
these
anabolic
agents
on
the
healing
of
ischemic
colon
in
rats.
METHODS:
Seventy
adult
male
Wistar
rats
were
divided
into
five
groups
(n
=
14).
Group
I
was
the
sham
laparotomy
group.
In
the
other
groups,
surgical
procedures
consisting
of
transsection
and
anastomosis
were
made
at
a
distance
3
cm
from
the
peritoneal
reflec-
tion.
Group
II
was
the
nonischemic
control
group.
Isch-
emic
colon
model
was
produced
in
the
remaining
groups.
Group
III
was
the
untreated
control
group.
Groups
IV
and
V
received
recombinant
human
growth
hormone
and
nandrolone
phenylpropionate,
respec-
tively.
Bursting
pressure
and
hydroxyproline
levels
were
measured
on
the
third
and
seventh
postoperative
days
to
evaluate
anastomotic
healing.
RESULTS:
Recombinant
hu-
man
growth
hormone
increased
both
collagen
deposition
and
bursting
pressure
significantly
at
postoperative
Days
3
and
7
compared
with
the
sham
and
untreated
control
groups
(P
<
0.005).
When
compared
with
the
untreated
control,
nandrolone
phenylpropionate
significantly
in-
creased
collagen
deposition
at
postoperative
Days
3
and
7
(P
<
0.005)
and
bursting
pressure
only
at
postoperative
Day
3
(P
<
0.005).
CONCLUSIONS:
Recombinant
human
growth
hormone
has
more
favorable
therapeutic
effects
on
the
healing
of
ischemic
colonic
anastomoses
than
nandrolone
phenylpropionate.
Recombinant
human
growth
hormone
also
improves
healing
of
nonischemic
colonic
anastomosis.
PURPOSE:
Recombinant
human
growth
hormone
and
nandrolone
phenylpropionate
are
two
different
anabolic
agents.
This
study
was
designed
to
investigate
the
effects
of
these
anabolic
agents
on
the
healing
of
ischemic
colon
anastomosis
in
rats.
METHODS:
Seventy
adult
male
Wistar
rats
were
divided
into
five
groups
(n
=
14).
Group
I
was
the
sham
laparotomy
group.
In
the
other
groups,
surgical
procedures
consisting
of
transsection
and
anastomosis
were
made
at
a
distance
3
cm
from
the
peritoneal
reflec-
tion.
Group
II
was
the
nonischemic
control
group.
Isch-
emic
colon
model
was
produced
in
the
remaining
groups.
Group
III
was
the
untreated
control
group.
Groups
IV
and
V
received
recombinant
human
growth
hormone
and
nandrolone
phenylpropionate,
respec-
tively.
Bursting
pressure
and
hydroxyproline
levels
were
measured
on
the
third
and
seventh
postoperative
days
to
evaluate
anastomotic
healing.
RESULTS:
Recombinant
hu-
man
growth
hormone
increased
both
collagen
deposition
and
bursting
pressure
significantly
at
postoperative
Days
3
and
7
compared
with
the
sham
and
untreated
control
groups
(P
<
0.005).
When
compared
with
the
untreated
control,
nandrolone
phenylpropionate
significantly
in-
creased
collagen
deposition
at
postoperative
Days
3
and
7
(P
<
0.005)
and
bursting
pressure
only
at
postoperative
Day
3
(P
<
0.005).
CONCLUSIONS:
Recombinant
human
growth
hormone
has
more
favorable
therapeutic
effects
on
the
healing
of
ischemic
colonic
than
nandrolone
growth
hormone
of
colonic
anastomosis.