Expression of KIR and C-type lectin receptors in Behcet's disease

SARUHAN-DIRESKENELI G., UYAR F. A., CEFLE A., ONDER S., EKSIOGLU-DEMIRALP E., KAMALI S., ...More

RHEUMATOLOGY, vol.43, no.4, pp.423-427, 2004 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 43 Issue: 4
  • Publication Date: 2004
  • Doi Number: 10.1093/rheumatology/keh063
  • Journal Name: RHEUMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.423-427
  • Keywords: Behet's disease, NK cell, KIR3DL1, CD94, HLA-B51, HLA-Bw4, HUMAN T-LYMPHOCYTES, HLA-B, INHIBITORY RECEPTORS, CELLS, RECOGNITION, MOLECULES, NKB1, PHENOTYPES, ACTIVATION, ARTHRITIS
  • Istanbul University Affiliated: Yes

Abstract

Objective. Behcet's disease (BD) is a multisystemic disorder with a possible underlying pathology of immune-mediated vasculitis. Genetic susceptibility associated with HLA-B*51 and B*2702 has been implicated in its pathogenesis. Considering the recently defined regulatory mechanisms of NK cells through HLA class I binding receptors, we hypothesized that interactions of NK and T cells through the NK receptors may be important in the pathogenesis of BD.