Oxytocin as a protective agent in cisplatin-induced ototoxicity

Bılmez Z. E. B., Aydin S., Sanlı A., Altıntoprak N., Demir M. G., Erdogan B. A., ...Daha Fazla

CANCER CHEMOTHERAPY AND PHARMACOLOGY, cilt.77, sa.4, ss.875-879, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 4
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1007/s00280-016-2978-x
  • Dergi Adı: CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.875-879
  • İstanbul Üniversitesi Adresli: Hayır

Özet

Cisplatin is a potent chemotherapeutic drug with serious side effects such as ototoxicity which is characterized by irreversible, bilateral, progressive sensorineural hearing loss. Oxytocin, which is a well-known hormone secreting during pregnancy, has antioxidant and antiinflammatory effect. Our study aims to test and compare the effect of intratympanic (IT) and intraperitoneal (IP) oxytocin on cisplatin ototoxicity with DPOAE.