Methylenetetrahydrofolate reductase gene polymorphisms in patients with schizophrenia

Sazci A., Ergul E., Guzelhan Y., Kaya G., Kara I.

MOLECULAR BRAIN RESEARCH, vol.117, no.1, pp.104-107, 2003 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 117 Issue: 1
  • Publication Date: 2003
  • Doi Number: 10.1016/s0169-328x(03)00327-9
  • Journal Name: MOLECULAR BRAIN RESEARCH
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.104-107
  • Istanbul University Affiliated: No

Abstract

To investigate the role of methylenetetrahydrofolate reductase gene polymorphisms in schizophrenia, we analyzed the genotypes of MTHFR677 and MTHFR1298 of 130 schizophrenic patients and 226 controls, using a polymerase chain reaction restriction fragment length polymorphism method. The MTHFR T677 allele was significantly distributed (chi(2) = 7.900; P = 0.019), between schizophrenic cases and healthy controls. The T677T genotype was overrepresented in the schizophrenic patients (OR = 2.504; 95% CI = 1.276-4.915; 2 chi(2) = 7.477; P = 0.006). The T677T/A1298A, and C677T/C1298C compound genotypes were greater in the schizophrenic patients, (OR = 3.157; 95% CI = 1.522-6.545; chi(2) = 10.336; P = 0.001 and OR = 1.744; 95% CI = 0.108-28.121; chi(2) = 0.158; P = 0.691, respectively). The MTHFR T677 allele and T677T and T677T/A1298A genotypes are genetic risk factors for schizophrenia. (C) 2003 Elsevier B.V. All rights reserved.