The effect of intraarticular botulinum toxin-A injection on symptoms of temporomandibular joint disorder

Sari B. C., DEVELİ T.

JOURNAL OF STOMATOLOGY ORAL AND MAXILLOFACIAL SURGERY, vol.123, no.5, 2022 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 123 Issue: 5
  • Publication Date: 2022
  • Doi Number: 10.1016/j.jormas.2022.04.019
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
  • Keywords: Arthrocentesis, Botulinum toxin, Intra-articular, ARTHROCENTESIS, OSTEOARTHRITIS, ARTHRITIS, VOLUME
  • Istanbul University Affiliated: No


Introduction: Application of arthrocentesis in temporomandibular joint disorders preferred and suggested therapeutic treatment option in recent years. This study was designed to investigate and compare the effect of intra-articular injection of botulinum toxin-A (Btx-A) on pain and mouth opening after arthrocentesis in nonreduction disc displacement.Materials and methods: This restrospective study was conducted on 30 patients with a visual analogue scale is higher than five and limited mouth opening. Patients were divided into 2 groups as conventional arthrocent-esis group (group A) and intra-articular Btx-A injection following arthrocentesis group (group B). Maximum mouth openining and temporomandibular joint pain were measured in preoperative (t0) and at postopera-tive 1st-week (t1), 1st-month (t2) and 6th-month (t3).Results: When VAS scores of group A and group B were examined, no statistical difference was observed at t0 and t1 time intervals; an increased in mouth opening values and decreased VAS score values were observed in both groups in the 1st month (t2) and 6th (t3) months, mostly in group A.Conclusion: I_ntra-articular injection of Btx-A following arthrocentesis can induce mouth opening and reduce the pain and dysfunction in patients with anterior disc displacement.(c) 2022 Elsevier Masson SAS. All rights reserved.