Stevens Johnson Syndrome - Toxic Epidermal Necrolysis Induced by A Combination of Lamotrigine and Valproic Acid: A Case Report

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Atıf İçin Kopyala

Oflaz S., Kalkan H. S., Gokce E., Karsidag C., Gurel M. S.

KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY, cilt.21, sa.2, ss.150-153, 2011 (SCI-Expanded)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 21 Sayı: 2
• Basım Tarihi: 2011
• Doi Numarası: 10.5455/bcp.20110410031809
• Dergi Adı: KLINIK PSIKOFARMAKOLOJI BULTENI-BULLETIN OF CLINICAL PSYCHOPHARMACOLOGY
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
• Sayfa Sayıları: ss.150-153
• İstanbul Üniversitesi Adresli: Evet

Özet

Both Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare and life-threatening acute allergic reactions affecting the skin and mucous membranes. We report a case with SJS-TEN likely induced by inappropriate lamotrigine titration during the use of a lamotrigine and valproic acid regimen. The present case report supports the clinical evidence that combination of lamotrigine with other psychiatric drugs increases the frequency and severity of skin reactions. Therefore in polypharmacy, lamotrigine should be used more carefully and lamotrigine should be discontinued if any rash appears.