Penetration of moxifloxacin into rat mandibular bone and soft tissue

Cachovan G., Nergiz I., Thuss U., Siefert H., Sobottka I., Oral O., ...Daha Fazla

ACTA ODONTOLOGICA SCANDINAVICA, cilt.67, sa.3, ss.182-186, 2009 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 67 Sayı: 3
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1080/00016350902787564
  • Dergi Adı: ACTA ODONTOLOGICA SCANDINAVICA
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.182-186
  • Anahtar Kelimeler: Animal study, antibiotics, odontogenic infections, plasma and tissue concentrations, OROFACIAL ODONTOGENIC INFECTIONS, IN-VITRO ACTIVITY, CLINDAMYCIN, ABSCESSES, BACTERIA, 8-METHOXYQUINOLONE, PHARMACOKINETICS, METRONIDAZOLE, ARTHROPLASTY, PROPHYLAXIS
  • İstanbul Üniversitesi Adresli: Evet

Özet

Objective. Based on its in vitro activity and spectrum of activity, the new 8-methoxyquinolone antibiotic moxifloxacin (MXF) seems suited for the antibiotic therapy of odontogenic infections. Penetration into the relevant tissue is another prerequisite for clinical efficacy. For this reason, the levels of MXF in plasma, soft tissue, and mandibular bone were determined in an animal model with Wistar rats. Material and methods. Samples of 49 rats were analyzed. Tissue samples were homogenized and proteins were precipitated. The pharmacokinetic evaluation was conducted based on non-compartmental analysis. Results. The concentration-time courses of tissues show a more plateau-shaped curve compared to plasma. Calculated AUC (area under the curve) ratios tissue:plasma were M. masseter:plasma = 2.64 and mandibles:plasma = 1.13. Conclusions. Administration of antibiotics is considered an important part of therapy during and/or after surgical procedures in the maxillofacial area. Because of the good penetration into bone and muscle tissues demonstrated in Wistar rats, MXF might be an option for clinical application in this indication.