Differential Pulse Voltammetric Determination of Montelukast in Tablets and Human Plasma by Using Chitosan Modified Carbon Paste Electrode

Yıldız G., Aydogmus Z., Kauffmann J.

ELECTROANALYSIS, cilt.25, sa.7, ss.1796-1802, 2013 (SCI-Expanded, Scopus)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 25 Sayı: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.1002/elan.201300077
  • Dergi Adı: ELECTROANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1796-1802
  • İstanbul Üniversitesi Adresli: Evet

Özet

Electrochemical reduction and determination of montelukast (MKS) was studied in methanol – 0.1 M HCl solution

(1 :1, v/v) by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) at chitosan modified carbon paste

electrode. The linear range was 1.70107–1.83105 M for DPV analysis. Limit of detection (LOD) and limit of

quantification (LOQ) were 5.32108 M and 1.61107 M, respectively. The developed method was successfully applied

to the determination of MKS in tablets and spiked human plasma. The results obtained were in good agreement

with those obtained using a reported spectrofluorimetric technique.