Population-Specific Genetic Variation of TRAIL in Ovarian Cancer


Farooqi A. A., Mansoor Q., Rehman A., Fayyaz S., Ismail M.

PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES, vol.7, no.2, pp.486-487, 2013 (ESCI) identifier identifier

  • Publication Type: Article / Article
  • Volume: 7 Issue: 2
  • Publication Date: 2013
  • Journal Name: PAKISTAN JOURNAL OF MEDICAL & HEALTH SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, EMBASE
  • Page Numbers: pp.486-487
  • Keywords: Polymorphism, exon, TRAIL
  • Istanbul University Affiliated: No

Abstract

Objective: Genome-wide, high-throughput technologies have made major advances in understanding the molecular basis of ovarian cancer and contribution of a single genetic variant, multiple genetic variants, and the contribution of cumulative effect of a genetic variant and an environmental factor to the difference in the incidence of disease have been extensively studied. There is a progressive increase in the studies related to TRAIL mediated signaling and it has been reported that there is a highly polymorphic region in the TRAIL promoter with four SNPs located in a 111 base pair (bp) spanning sequence between nucleotides 707 and 597 upstream of the transcriptional start site.