Akademik Veri Yönetim Sistemi
Anatolian Journal of Clinical Investigation, cilt.4, sa.1, ss.11-14, 2010 (Scopus)
The aims of the present study were to investigate the prevalence of nasopharyngeal carriage of Streptococcus pneumoniae and to determine the antibiotic resistance patterns and serotypes in healthy children attending day care centre at 0, 3 and 6th months. A total of 295 healthy children (age ranged: 4-7) attending the five day care centres were included to the study. The isolation and identification of S. pneumoniae strains from nasopharyngeal samples were performed by conventional culture methods. Antibiotic sensitivity tests were done according to the Clinical Laboratory Standards Institute directions by disk diffusion method, and penicillin MIC values were detected by microdilution method. S. pneumoniae were isolated 18.6% (55) children at the first day attended the day care but nasopharyngeal carriage were reached 34.6% at the third month, 47.1% at the sixth month. The susceptibility rate of the isolates to penicilin was found as 68.7%, while 10.2% of the strains yielded high resistance against penicillin. Overall percentages of resistance to rifampicin, erythromycin and clindamycin were 16.3%, 23.5% and 9.6%, respectively. Multidrug resistant S. pneumoniae was detected in 8 (4.8%) of strains. The most frequent serotypes associated with penicillin resistance were serotypes 6, 8, 9, 15, 19, 20 and 23. Finally, this study shows that staying in day-care centres is very important risk factors for S. pneumoniae carrier state. Due to most isolated and penicillin resistant strains covered by 7-valent vaccine, suggesting that its use could reduce the incidence of pneumococcal disease.