Association of HLA-DRB1*15 and HLA-DQB1*06 with SLE in Saudis

Al-Motwee S., Jawdat D., Jehani G. S., Anazi H., Shubaili A., Sutton P., ...Daha Fazla

ANNALS OF SAUDI MEDICINE, cilt.33, sa.3, ss.229-234, 2013 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 33 Sayı: 3
  • Basım Tarihi: 2013
  • Doi Numarası: 10.5144/0256-4947.2013.229
  • Dergi Adı: ANNALS OF SAUDI MEDICINE
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.229-234
  • İstanbul Üniversitesi Adresli: Evet

Özet

BACKGROUND AND OBJECTIVES: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by humoral autoimmunity. The etiology of SLE is thought to be multifactorial including environmental, hormonal, and genetic factors. The human leukocyte antigen (HLA) has extensively been associated with the susceptibility to SLE; however, the association is heterogeneous among different ethnic groups. The aim of this study was to determine the association of HLA-A, HLA-B, HLA-DRB1, and HLA-DQB1 with SLE susceptibility in the Saudi population.