The effects of atorvastatin on memory deficit and seizure susceptibility in pentylentetrazole-kindled rats

Uzum G., Akgun-Dar K., Aksu U.

EPILEPSY & BEHAVIOR, cilt.19, sa.3, ss.284-289, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1016/j.yebeh.2010.07.024
  • Dergi Adı: EPILEPSY & BEHAVIOR
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.284-289
  • Anahtar Kelimeler: Epilepsy, Kindling, Memory, Pentylenetetrazole, Atorvastatin, Passive avoidance, COGNITIVE IMPAIRMENT, STATUS-EPILEPTICUS, CELL-DEATH, PENTYLENETETRAZOL, STATINS, SIMVASTATIN, CONSEQUENCES, CHOLESTEROL, MECHANISM, EPILEPSY
  • İstanbul Üniversitesi Adresli: Evet

Özet

Deficits in memory function have been observed in pentylentetrazole (PTZ)-kindled rats. In the present study we examined the effects of atorvastatin ((3-hydroxy-3-methylglutaryl-coenzyme A [HMG-CoA] reductase inhibitor) on PTZ kindling and related memory deficits in rats trained with the passive avoidance test. Subconvulsive PTZ doses rendered a gradual increase in seizure activity. PTZ kindling caused long-term memory to deteriorate. Atorvastatin per se and in PTZ-kindled rats improved learning and memory functions. It also prolonged latency (time to appearance of spike potentials) and diminished the amplitude and frequency of spike potentials, which indicate epileptic discharges. These novel findings suggest that the favorable effect of the atorvastatin on memory deficits provoked by PTZ kindling might be of clinical utility. (C) 2010 Elsevier Inc. All rights reserved.