Effects of methylprednisolone pulse therapy on insulin injections in patients with insulin-dependent diabetes mellitus

Satman I., Ficicioglu C., Karsidag K., Yilmaz T., Dincdag N., Koca F., ...More

TURKISH JOURNAL OF PEDIATRICS, vol.38, no.4, pp.419-429, 1996 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 4
  • Publication Date: 1996
  • Journal Name: TURKISH JOURNAL OF PEDIATRICS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.419-429
  • Istanbul University Affiliated: Yes

Abstract

In this study we evaluated 31 insulin-dependent diabetes mellitus (IDDM) patients (ages 12.1+/-3.4 years, 18 males/13 females) who started on multiple subcutaneous insulin injections (MSII) within six weeks of diagnosis and achieved either complete (CR: no insulin requirement and near-normoglycemia for at least two weeks) or incomplete (ICR: minimum 50% decline in insulin requirement while maintaining near-normoglycemia for two weeks or more) remissions within the first 12 weeks of the MSII trial. Methylprednisolone pulse therapy (MP) was administered four times per day by IV bolus at a dose of 30 mg/kg (max. 1000 mg) on alternate days.