IL-1β and glycemia levels are inversely proportional in early period of allo- and xeno-transplantation of islets of Langerhans

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Gürol A. O. , Süzergöz F., Küçüksezer U. C. , Çevik A. , Deniz G.

Metabolic and Functional Research on Diabetes (Online) , vol.3, pp.15-19, 2010 (Refereed Journals of Other Institutions)

  • Publication Type: Article / Article
  • Volume: 3
  • Publication Date: 2010
  • Journal Name: Metabolic and Functional Research on Diabetes (Online)
  • Page Numbers: pp.15-19


The aim of diabetes treatment must be to obtain normal glucose metabolism and prevent or reverse the late complications of the disease. Interest in islet transplantation for type 1 diabetes treatment is increasing, but immune mediated graft rejection is still a major concern at the time of transplantation. Previous findings have shown that interleukin 1-beta (IL-1β) is important in initiating β-cell dysfunction and cellular damage. In this study, IL-1β release and its relationship to glycemia levels
following transplantation of allo- or xenogeneic islets of Langerhans into the liver of healthy and diabetic rats were investigated. IL-1β and glycemia levels were found to be inversely related in early post-transplant period. Monitoring cytokine profiles of
recipients, especially in peri-transplant period, seems to be a promising measure of graft functioning.