Voriconazole Induced Bradycardia


Uludag D., Ozdemir N. , Tuysuz G. , Eroglu A. G. , Celkan T.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.30, ss.674-676, 2013 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 30 Konu: 7
  • Basım Tarihi: 2013
  • Doi Numarası: 10.3109/08880018.2013.775616
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Sayfa Sayıları: ss.674-676

Özet

Voriconazole is a triazole antifungal drug that is used to treat invasive fungal infections, especially aspergillus. Here, we report two children who had severe bradycardia associated with voriconazole at a dose of 12 mg/kg per day. Bradycardia resolved in 24 hours in both after decreasing the dose to 10 mg/kg per day. Heart rates were in normal limits on follow-up. Bradycardia may be a side effect of voriconazole treatment in children under immunosuppressive treatment. Heart rate should be monitored in patients receiving voriconazole and other triazole treatments.